Related Papers
Evidence-Based Complementary and Alternative Medicine
Antiamnesic and Neuroprotective Effects of an Aqueous Extract of Ziziphus jujuba Mill. (Rhamnaceae) on Scopolamine-Induced Cognitive Impairments in Rats
Sefirin DJIOGUE
Background. Alzheimer's disease is a neurological condition that affects about 44 million people worldwide. The available treatments target symptoms rather than the underlying causes. Ziziphus jujuba (Rhamnaceae) is widely used in traditional Cameroonian medicine to treat diabetes, pain, infections, and dementia. Previous studies reported that Z. jujuba aqueous macerate improves working memory impairment, but no study on the antiamnesic effect of a concoction of Z. jujuba in rats has been performed. Therefore, this study aimed to assess the antiamnesic and neuroprotective effects of an aqueous extract of Z. jujuba on scopolamine-induced cognitive impairments in rats. Methods. Learning and memory impairments were induced in rats by administering scopolamine (1 mg/kg, i.p.) to 58 rats for 15 days. Rats that developed learning and memory impairments in Morris water maze and Y-maze paradigms were divided into 7 groups (8 rats each) and treated daily for 15 days as follows: the norma...
Anti-Amnesic and Neuroprotective Effects of Ziziphus Jujuba Aqueous Extract on Scopolamine-Induced Cognitive Impairments in Rats
Sefirin DJIOGUE
Background: Alzheimer's disease is a neurological condition that affects more than 44 million people worldwide. The available treatments target the symptoms rather than underlying causes. Ziziphus jujuba (Rhamnaceae) is used in traditional Cameroonian medicine to treat many disorders including memory impairments. The study aimed to evaluate the anti-amnesic and neuroprotective effects of Z. jujuba aqueous extract on scopolamine-induced memory disorders in rats. Methods: Learning and memory impairments were induced in rats by scopolamine (1mg/kg, i.p.) for 15 days. Rats that developed cognitive impairments were divided as follows: two positive control groups received piracetam (200 mg/kg, p.o.) or tacrine (1 mg/kg, p.o.); three test groups received the extract (29, 57, and 114 mg/kg, p.o., respectively) daily for 15 days. At the end of treatments, memory impairments were assessed by Morris water maze and Y-maze tests. Thereafter, animals were sacrificed and some biochemical param...
Avicenna Journal of Phytomedicine
The effect of hydroalcoholic extract of Ziziphora clinopodioides L. on spatial memory and neuronal density of hippocampal CA1 region in rats with sporadic Alzheimer's disease
2019 •
Samaneh Sedighi
Objective: Alzheimer's disease is a neurodegenerative disorder associated with gradual loss of cognitive and memory abilities. It was shown that the hippocampus is one of the first structures in the brain that is affected by the disease. Ziziphora clinopodioides (Z. clinopodioides) is a member of Lamiaceae family and contains various substances. Materials and Methods: In this experimental study, 72 adult male Wistar rats were used for behavioral and histopathologic studies. They were divided into nine groups included: control, negative control (Alzheimer), positive control (Alzheimer's treated with rivastigmine), aCSF (artificial cerebrospinal fluid) + ziziphora extract with doses of 200,400, and 600 mg/kg, and STZ (stereptozotocine)+ziziphora extract in 200,400,600 mg/kg doses. The injury was created with bilaterally intraventricular injection. The spatial memory was studied by passive avoidance test and neuronal density was evaluated by dissector method. To examine the his...
CNS Neuroscience & Therapeutics
Amelioration of Amyloid β-Induced Cognitive Deficits by Zataria multiflora Boiss. Essential Oil in a Rat Model of Alzheimer's Disease
2012 •
Mohammad Kamalinejad
Lancet
A modified formulation of Chinese traditional medicine improves memory impairment and reduces A� lev
2011 •
Songhee Jeon
SuHeXiang Wan (SHXW), a Chinese traditional medicine has been used orally for the treatment of seizures, infantile convulsion, stroke and so forth. Previously, we reported the effects of modified SHXW essential oil mixture of the fragrance containing herbs on the sedative effect, anticonvulsant property and antioxidative activity after fragrance inhalation.This study was undertaken to evaluate beneficial effects of a modified recipe of SHXW (termed as KSOP1009) consisting of a ethanol extract of 8 herbs including resin of Liquidambar orientalis Miller, seed of Myristica fragrans Houtt., rhizome of Cnidium officinale Makino, lumber of Santalum album L., fructus of Piper longum L., flower buds of Eugenia caryophyllata Merrill et Perry, pollen of Typha orientalis Presl., and root of Salvia miltiorrhiza Bunge in the neurodegenerative diseases such as Alzheimer's disease (AD). The transgenic mice of AD, Tg-APPswe/PS1dE9, were fed KSOP1009 or as a positive control, donepezil for 3 months from 4.5 months of age. Behavioral, immunological and ELISA analyses were used to assess memory impairment, Aβ accumulation and plaque deposition in the brain. Other in vitro works were performed to examine whether KSOP1009 inhibits the Aβ1–42-induced neurotoxicity in human neuroblastoma cell line, SH-SY5Y cells.Intake of KSOP1009 improved the Aβ-induced memory impairment and suppressed Aβ levels and plaque deposition in the brain of Tg-APPswe/PS1dE9 mice as much as that of donepezil treatment. KSOP1009 prevented the down-regulation of phospho-CREB and increased AKT phosphorylation in the AD-like brains. Moreover, KSOP1009 suppresses Aβ-induced apoptosis and ROS production in SH-SY5Y cells.The present study suggests that KSOP1009 may develop as a therapeutic drug for treatment of AD patients.
Protective effects of Ziziphus jujuba fruit extract against ethanolinduced hippocampal oxidative stress and spatial memory impairment in rats
2011 •
Bahram Rasoulian, Masoud Alirezaei
Research Paper: Neuroprotective Effect of Zataria Multiflora Essential Oil on Rats With Alzheimer Disease: A Mechanistic Study
2019 •
Basic and Clinical Neuroscience Journal
Introduction: Finding herbs with promising effects to prevent or postpone Alzheimer Disease (AD) is highly demanded. The present study aimed at clarifying plausible effects and related mechanism(s) of Zataria Multiflora Essential Oil (ZMEO) against memory impairment in a rat model of the AD. Methods: Forty male adult rats were categorized into four groups and treated as follows: 1. The Negative Control (NC): no treatment; 2. Sham control (sham): distilled water by Intracerebroventricular (ICV) injection; 3. The AD control (AD): Aβ 1-42 by ICV injection; and 4. The ZMEO group: Aβ 1-42 by ICV injection and ZMEO at 100 μL/kg/d orally for 20 days. Results: After Congo red staining of the hippocampus, a relative decrease in amyloid deposits was observed in the ZMEO group. Moreover, rats showed better outcomes in Morris Water Maze (MWM) test, reduced hippocampal acetylcholinesterase (AchE) activity, and higher Brain-Derived Neurotrophic Factor (BDNF) content as compared with the AD group (P<0.05). However, no significant changes in antioxidant status was observed (P>0.05). Conclusion: ZMEO has a protective effect against memory impairment in rats with AD at least partly via reducing hippocampal AchE activity and enhancement of BDNF levels without a change in antioxidant status. These findings can pave the way for future studies on the usefulness of this herb in AD prevention.
Avicenna Journal of Neuro Psych Physiology
Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring
2016 •
Minoo Mahmoodi
Advances in Alzheimer's Disease
Effects of <i>Syzygium cumini</i> Seed Extract on the Memory Loss of Alzheimer’s Disease Model Rats
asiqur rahaman
The Effect of 6-Week Interval and Continuous Training with Zizphus Vulgaris Extract Supplementation on Hippocampus’s BDNF Male Wistar Rats
2020 •
Hadi Sarir
Background: The aim of the study was to compare the effect of 6-week interval and Continuous training with Zizphus Vulgaris Extract supplementation on the hippocampus’s BDNF male Wistar rats. Methods: Among 36 male rats (250-350 gr), randomly after adjusting the body weight, 6 rats were separated as the control group. 30 rats were divided into 5 groups: Continuous group (n=6), Interval group (n=6), Continuous with Zizphus Vulgaris Extract group (n=6), Interval with Zizphus Vulgaris Extract group (n=6) and Zizphus Vulgaris Extract group (n=6). The training groups completed 8 weeks of the training program, 5 days/week according to protocol. The Endurance Continuous protocol includes running exercise on a treadmill for, 10 m/min, 10 min/day to up 16 m/min, 40 min/ day. Endurance Interval protocol includes running exercise on a treadmill for, 5*4 min, with intensity 10 m/min to up 23 m/min, 52 min/ day. The Zizphus Vulgaris Extract group, every 6 weeks, each rat consumed 400 mg/kg.day ...
